John P . Johnson and James D . Stockand ALDOSTERONE
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ALDOSTERONE You might find this additional info useful... specialized courses and in the broader context of general biology education. It is published four times a year in is dedicated to the improvement of teaching and learning physiology, both in
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Aldosterone.
Aldosterone plays a pivotal role in electrolyte and fluid homeostasis and thus control of blood pressure. The "classical" view of aldosterone action is that it targets epithelia of the distal colon and renal nephron to stimulate Na(+) (re)absorption and K(+) secretion. In these cells, aldosterone binds steroid receptors, promoting translocation to the nucleus, where they modulate gene expressio...
متن کاملCALL FOR PAPERS Aldosterone and ENaC: From Genetics to Physiology Regulation of Na transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades
Tong, Qiusheng, Rachell E. Booth, Roger T. Worrell, and James D. Stockand. Regulation of Na transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades. Am J Physiol Renal Physiol 286: F1232–F1238, 2004. First published March 23, 2004; 10.1152/ajprenal.00345. 2003.—Cross talk between the phosphatidylinositol 3-kinase (PI3-K) and mitogen-activating prote...
متن کاملAldosterone-independent regulation of the epithelial Na+ channel (ENaC) by vasopressin in adrenalectomized mice.
The epithelial Na(+) channel (ENaC) in the aldosterone-sensitive distal nephron (ASDN) is under negative-feedback regulation by the renin-angiotensin-aldosterone system in protection of sodium balance and blood pressure. We test here whether aldosterone is necessary and sufficient for ENaC expression and activity in the ASDN. Surprisingly, ENaC expression and activity are robust in adrenalectom...
متن کاملNew ideas about aldosterone signaling in epithelia.
The systemic actions of aldosterone are well documented; however, in comparison, our understanding of the cellular and molecular mechanisms by which aldosterone orchestrates these actions is rudimentary. Aldosterone exerts most of its physiological actions by modifying gene expression. It is now apparent that aldosterone represses almost as many genes as it induces. Several aldosterone-sensitiv...
متن کاملEpithelial sodium channels are activated by furin-dependent proteolysis.
Epithelial Na(+) channels (ENaCs) are activated by extracellular trypsin or by co-expression with channel-activating proteases, although there is no direct evidence that these proteases activate ENaC by cleaving the channel. We previously demonstrated that the alpha and gamma subunits of ENaC are cleaved during maturation near consensus sites for furin cleavage. Using site-specific mutagenesis ...
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تاریخ انتشار 2002